Objective To study the application value of blood-activating and stasis-resolving method in the treatment of chloasma. Methods A total of 150 patients with chloasma admitted to our hospital from January 2020 to June 2021 were selected as the study subjects. According to the random number table method, the patients were divided into reference group and experimental group, with 75 cases in each group. Patients in the control group were treated with routine treatment, while patients in the experimental group were treated with the blood-activating and stasis-resolving method. The clinical efficacy, occurrence of adverse reactions, skin area, skin color and quality of life of the two groups were compared. Results The total effective rate of the experimental group was higher than that of the reference group, and the difference was statistically significant (P＜0.05). The incidence of adverse reactions in the experimental group was lower than that in the reference group, and the difference was statistically significant (P＜0.05). After treatment, the skin area and skin color score of experimental group were lower than that of reference group, and the differences were statistically significant (P＜0.05). The scores of quality of life in the experimental group were higher than those in the control group after treatment, and the difference was statistically significant (P＜0.05). Conclusion The method of promoting blood circulation and removing blood stasis is effective in chloasma patients with low incidence of adverse reactions. It can effectively reduce the area of skin lesions, improve the color of skin lesions, and improve the quality of life of patients, which is worthy of clinical reference and promotion.