Objective To explore the clinical effectof ultra-pulsed carbon dioxide lattice laser in the treatment of stable vitiligo. Methods A total of 80 patients with stable vitiligo admitted to our hospital from January 2019 to October 2020 were divided into control group (n=40) and experimental group (n=40) by simple randomization method. The control group was treated with conventional drugs, and the experimental group was treated with ultra-pulsed carbon dioxide lattice laser on the basis of the control group. The therapeutic effect,quality of life score, inflammatoryfactor level and adverse reactions were compared between the two groups. Results The total effectiverate of the experimental group was 90.00%, which was higher than 70.00% of the control group (P<0.05). The quality of life scores of the two groups after treatment were higher than those before treatment, and the quality of life score of the experimental group was higher than that of the control group (P<0.05). The levels of inflammatoryfactors in the two groups were lower than those before treatment, and the experimental group was lower than the control group (P<0.05). There was no significan differencein the incidence of adverse reactions between the two groups (P>0.05). Conclusion Compared with conventional drug therapy, ultra-pulsed carbon dioxide lattice laser has better therapeutic effect,which can effectivelyimprove the quality of life, reduce the level of inflammatory factors, and does not increase adverse reactions. It is a safe and effective treatmen