Objective To investigate the application effct of orbital septum fixtion combined with modifiedmyocutaneous flapplastic surgery in eye bag surgery. Methods A total of 460 patients who underwent eye bag surgery were admitted to Xi'an Gaoyisheng Medical Beauty Hospital from January 2017 to November 2021 were selected as the research objects and divided into the control group and the study group according to the random number table method, with 230 cases in each group. The control group was treated with traditional musculocutaneous flap,and the study group was treated with orbital septum fixationcombined with modifiedmyocutaneous fap. The therapeutic effect,treatment time, skin appearance recovery time, eye skin beauty score change, incidence of adverse events and cosmetic satisfaction rate of patients were compared between the two groups. Results The total effectiverate of the study group was 95.65%, which was higher than 80.00% of the control group, and the differenc was statistically significant(P<0.05). The treatment time and skin appearance recovery time of the study group were shorter than those of the control group, and the eye skin beauty score after treatment was higher than that of the control group, the differencewas statistically significant(P<0.05). The incidence of adverse events in the study group was lower than that in the control group, and the cosmetic satisfaction rate was higher than that in the control group, the differencewas statistically significant(P<0.05). Conclusion Orbital septal fixationcombined with modifiedmyocutaneous flapplastic surgery can effectivelyimprove the beauty of eye skin, patients' satisfaction is high, and the postoperative recovery is fast, the curative effectis exact, and the incidence of adverse events is low, which has high application value in eye bag surgery.