Cutaneous squamous cell carcinoma is a malignant tumor with high incidence, rapid development, metastasis, and easy misdiagnosis, which poses a threat to human health. With the development of traditional Chinese medicine and the progress of modern medical experimental research technology, traditional Chinese medicine has also made some achievements in the modern research of cutaneous squamous cell carcinoma. At present, the clinical treatment of cutaneous squamous cell carcinoma mostly adopts surgery, and drug chemotherapy. Due to the existence of adverse reactions, patients have low acceptance. Traditional Chinese medicine has the advantages of multi-target, high safety and less adverse reactions. Traditional Chinese medicine has certain advantages in the treatment of cutaneous squamous cell carcinoma. This paper will focus on the research progress of traditional Chinese medicine monomer, traditional Chinese medicine compound, and acupuncture in the treatment of cutaneous squamous cell carcinoma.