Objective To analyze the nursing effect of predictive nursing intervention on patients with severe acne. Methods A total of 70 patients with severe acne admitted to our hospital from June 2020 to June 2021 were selected as the research objects and divided into control group and observation group according to different nursing methods, with 35 cases in each group. The control group was given routine nursing, and the observation group was given predictive nursing intervention on the basis of routine nursing. The clinical treatment effect, immune function index, psychological state, quality of life score and complications were compared between the two groups. Results The total nursing rate of the observation group was 97.14%, which was higher than 68.57% of the control group, and the difference was statistically significant (P<0.05). After nursing, immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). The anxiety score (SAS) and depression score (SDS) in the observation group after nursing were lower than those in the control group, and the differences were statistically significant (P<0.05). The scores of quality of life in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Predictive nursing intervention for patients with severe acne can effectively improve the nursing efficacy, improve the immune function and quality of life, and reduce the incidence of adverse psychological emotions and complications.