Objective To explore the clinical efficacy of corticotomy assisted orthodontic treatment in patients with skeletal class Ⅱ malocclusion. Methods A total of 74 patients with skeletal class Ⅱ malocclusion admitted to our hospital from January 2020 to January 2021 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 37 cases in each group. The control group was treated with orthodontic treatment, and the observation group was treated with corticotomy assisted orthodontic treatment. The tooth position, soft tissue related variables, hard tissue related variables, upper dentition gap closure time and total correction time were compared between the two groups. Results U1I-CP and U1R-CP in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05), while there was no significant difference in U1R-HP, U1R-CP and U1-HP between the two groups (P>0.05). SNA, UARA and Sd-CP in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05), while there was no significant difference in A-HP, A-CP and Sd-HP between the two groups (P>0.05). The Ls-HP, Ls-CP and NLA in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05), while there was no significant difference in Sn-HP and Sn-CP between the two groups (P>0.05). The closure time of upper dentition space and the total correction time in the observation group were shorter than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The clinical effect of corticotomy assisted orthodontic treatment for patients with skeletal class Ⅱ malocclusion is definite. It can not only improve the tooth position of patients, but also effectively improve the soft and hard tissue related variables of patients, and shorten the correction time of patients, which is worthy of clinical application.