Objective To explore the effect of local use of antibiotics to prevent infection after conventional facial plastic surgery. Methods From May 2019 to February 2022, 180 patients who underwent routine facial plastic surgery in our hospital were randomly divided into observation group and control group, with 90 cases in each group. The high-risk patients in the control group and the observation group were divided into high-risk control groups (30 cases) and high-risk observation groups (28 cases). The control group was treated with eye infiltration ointment, and the observation group was treated with local antibiotics.The preventive effects of the two groups and two subgroups were compared. Results The wound infection rate in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incision dehiscence and allergic (contact) dermatitis between the two observation groups (P>0.05). There was no significant difference in the incidence of wound infection, incision dehiscence, and allergic (contact) dermatitis between the two high-risk subgroups (P>0.05). Conclusion Local use of antibiotics in facial plastic surgery can prevent wound infection without causing other complications, which is worthy of clinical application.