Objective To construct an intelligent blood glucose management system and evaluate its application effect in blood glucose management. Methods From January 2021 to June 2022, 40 inpatients with persistent abnormal blood glucose admitted to various clinical departments of our hospital were included in the study. According to the random number table method, they were divided into observation group and control group, with 20 cases in each group. The observation group was treated with intelligent blood glucose management system, and the control group was treated with routine blood glucose management. The blood glucose control effect, hospitalization days, complications, prognostic indicators, patient and medical staff satisfaction were compared between the two groups. Results There was no significant difference in FPG, 2 h PG and GA levels between the two groups during hospitalization (P>0.05). The levels of FPG, 2 h PG and GA in the observation group were lower than those in the control group at 1 week and 1 month after discharge (P<0.05). The hospitalization days of the observation group were shorter than those of the control group, and the total incidence of complications was lower than that of the control group (P<0.05). The control rate of blood glucose one month after discharge in the observation group was higher than that in the control group, and the incidence of hypoglycemia and readmission rate were lower than those in the control group (P<0.05). The satisfaction of the observation group was higher than that of the control group (P<0.05). The blood glucose monitoring pressure, timely change of treatment pressure and work efficiency improvement satisfaction in the observation group were higher than those in the control group (P<0.05). Conclusion The construction and application of intelligent hospital blood glucose management system can improve the effect of blood glucose control, reduce complications and readmission rate, and the satisfaction of patients and medical staff is high.