Objective To explore the clinical effect of rehabilitation nursing mode for acne patients. Methods A total of 88 patients with acne admitted to our hospital from October 2019 to October 2022 were selected as the research objects. They were divided into experimental group and reference group by random number table method, with 44 cases in each group. The reference group adopted the basic nursing mode, and the experimental group adopted the rehabilitation nursing mode on the basis of the reference group. The nursing satisfaction, psychological state and nursing effect of the two groups were compared. Results The total nursing satisfaction of the experimental group was 97.73%, which was higher than 84.09% of the reference group, the difference was statistically significant (P<0.05). After nursing, the SDS score and SAS score of the experimental group were lower than those of the reference group, the difference was statistically significant (P<0.05). The total effective rate of nursing in the experimental group was 95.45%, which was higher than 79.55% in the control group, and the difference was statistically significant (P<0.05). Conclusion The application effect of rehabilitation nursing mode in acne patients is ideal, which can improve nursing satisfaction, depression and anxiety of patients, and is conducive to improving the quality of nursing. It is worthy of clinical application.