Gastrointestinal endoscopy is mainly for the examiner's stomach, duodenum and esophagus, intestinal mucosa and other parts of the inspection, to observe whether there is erosion, inflammation, polyps and other lesions. Most examiners have fear of gastrointestinal endoscopy, and their cognitive level is low. Due to their different physical conditions, they will have different degrees of reaction, which is not conducive to the smooth progress of the examination. Therefore, in view of this situation, this paper reviews the overview, suitable population, preparation before examination and progress in diagnosis of gastrointestinal endoscopy combined examination, in order to improve the cooperation of examiners and the efficiency of examination.