Wound healing is largely dependent on the body's own repair capacity, and tissue damage can activate a variety of cells to secrete growth factors to participate in the inflammatory response process, regulate the synthesis and decomposition of proteins and other cellular components, thereby promoting cell proliferation, matrix formation, angiogenesis and granulation formation, to achieve the purpose of wound repair. Platelet-rich fibrin (PRF) is a second-generation platelet concentrate. Unlike platelet-rich plasma (PRP), PRF is prepared without anticoagulants and other chemical components, which effectively avoids allergic reactions. PRF is rich in growth factors and can continuously release growth factors for at least 1 week. At the same time, it has a good three-dimensional fibrin space structure, which can provide an ideal cell scaffold for the wound, effectively promote cell migration and proliferation, and thus promote wound healing. In order to explore the research progress of PRF in promoting acute wound healing, this paper reviews the wound healing process and the mechanism of PRF in acute wound healing.