Lacrimal groove depression can easily lead to facial haggardness and aging. Improving the lacrimal groove depression can achieve facial rejuvenation. Autologous fat free transplantation is one of the methods to correct lacrimal groove depression. It has the advantages of simple operation, good life compatibility and long maintenance time, and has been widely used in clinical practice. This article mainly reviews the development process of autologous fat free transplantation, and reviews the key issues such as the mechanism of lacrimal groove depression, the classification of lacrimal groove depression, the surgical method, the advantages and disadvantages of autologous fat transplantation, and complications, in order to increase the clinical understanding of free fat transplantation in lacrimal groove depression and reduce the incidence of postoperative complications.