Objective To explore the effect of type A botulinum toxin injection combined with hyaluronic acid filler in facial aesthetics. Methods From March 2021 to December 2022, 74 patients with facial skin filling admitted to the 969th Hospital of the Joint Logistics Support Force of PLA were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 37 cases in each group. The control group was treated with type A botulinum toxin, and the observation group was treated with type A botulinum toxin combined with hyaluronic acid. The clinical efficacy, complications, dignity and self-confidence scores, and treatment satisfaction were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group (P