Objective To investigate the effect of four-handed operation combined with psychological intervention in patients with orthodontics. Methods A total of 120 orthodontic patients admitted to the Orthodontic Department of Guilin Stomatological Hospital from September 2020 to September 2022 were selected as the research subjects. They were equally divided into control group and observation group by the random number table method, with 60 cases in each group. The control group was given conventional care, and the observation group was given four-handed operation combined with psychological intervention. The psychological condition, nursing satisfaction, pain level and tooth mobility were compared between the two groups. Results The SAS scores and SDS scores after nursing in the observation group were lower than those in the control group (P