Objective To evaluate the effect of psychological intervention on anxiety and pain in patients with facial chemical peeling. Methods A total of 62 patients with facial chemical peeling admitted to the outpatient department of Xianyang Central Hospital from July 2021 to December 2022 were selected as the research objects and divided into control group and observation group according to the random number table method, with 31 cases in each group. The control group was given routine nursing, and the observation group was given psychological intervention on the basis of the control group. The occurrence of pain, mood state and satisfaction were compared between the two groups. Results The total incidence of pain in the observation group was 9.68%, which was lower than 48.39% of the control group, and the difference was statistically significant (P