Objective To explore the clinical effect of comprehensive nursing intervention in patients with skin laser cosmetic treatment. Methods A total of 90 patients with skin laser cosmetic treatment admitted to our hospital from June to December 2021 were selected as the research objects. They were divided into reference group and study group by random number table method, with 45 cases in each group. The reference group was given traditional nursing intervention, and the study group was given comprehensive nursing intervention. The incidence of adverse reactions and nursing satisfaction were compared between the two groups. Results The total incidence of adverse reactions in the study group was 4.44%, which was lower than 26.67% in the reference group, the difference was statistically significant (P