Objective To explore the effect of pain nursing intervention on anxiety in patients with skin diseases treated by carbon dioxide laser. Methods From January to October 2022, 500 patients with skin diseases treated by carbon dioxide laser in the dermatology clinic of our hospital were selected as the research objects. They were divided into control group and observation group by random number table method, with 250 cases in each group. The control group was given routine nursing intervention, and the control group was given pain nursing intervention on the basis of the control group. The negative emotions, pain degree and nursing satisfaction of the two groups were compared. Results The nursing satisfaction of the observation group was higher than that of the control group (P