Objective To analyze the application of networked health education on oral cancer patients. Methods A total of 60 patients with oral cancer admitted to Taizhou People's Hospital from January 2020 to September 2021 were selected as the research objects and divided into control group and observation group by random number table method, with 30 cases in each group. The control group received routine nursing, and the observation group received networked health education on the basis of the control group. The hope level (HHI), self-esteem level (SSES) and quality of life (UW-QOL) were compared between the two groups. Results The HHI score and SSES score of the observation group was higher than that of the control group (P