Objective To explore the application value of GHK-Cu in basement membrane repair and facial rejuvenation. Methods A total of 31 subjects with facial rejuvenation needs from November to December 2022 were selected as the research subjects. They were treated with sodium crystal GHK-Cu basement membrane repair and treated with GHK-Cu essence for 28 consecutive days at home. The proportion of corneal wrinkle area, skin pore area, corneal wrinkle volume, area, number, facial skin gloss and satisfaction were compared before and 28 days after intervention. Results After 28 days of intervention, the proportion of corneal wrinkle area and skin pore area was less than that before intervention, and the difference was statistically significant (P