Objective To explore the application effect of intermittent remote tension reduction cosmetic suture in emergency patients with facial skin and soft tissue injury. Methods A total of 106 patients with facial skin and soft tissue injury admitted to our hospital from January to June 2022 were selected as the research objects. According to different surgical schemes, they were divided into control group (n=47) and observation group (n=59). The control group was treated with conventional surgical debridement and suture, and the observation group was treated with intermittent remote tension reduction cosmetic suture. The flap survival, healing, facial rehabilitation score (activity, sensation, appearance) and complications were compared between the two groups. Results The flap survival rate of the observation group was 96.61%, which was higher than 80.85% of the control group, and the difference was statistically significant (P0.05). Conclusion Intermittent remote tension reduction cosmetic suture is effective in emergency patients with facial skin and soft tissue injury, which can effectively improve the survival rate of skin flap, promote wound healing and recovery of facial skin and soft tissue activity, sensation and appearance function. Meanwhile, the risk of postoperative complications is small and the safety is high.