Objective To observe the application effect of local flap in wound repair after nasal skin tumor resection. Methods A total of 18 patients with nasal skin tumors admitted to our hospital from January 2021 to January 2022 were selected as the research objects. All patients underwent local skin flap repair after tumor resection. The clinical efficacy and aesthetic satisfaction of the 18 patients were observed, and the adverse psychological status and quality of life of the patients before and after treatment were compared. Results The total effective rate of 18 patients was 88.89%, and the satisfaction rate was 100.00%. After treatment, SAS score and SDS score were lower than those before treatment (P