Objective To analyze the clinical effect of CO2 lattice laser combined with salicylic acid in the treatment of depressed scar after acne. Methods A total of 60 patients with depressed scar after acne admitted to our hospital from January 2021 to June 2022 were selected as the research objects and divided into control group and observation group according to the random number table method, with 30 cases in each group. The control group was treated with CO2 lattice laser, and the observation group was treated with Borda salicylic acid on the basis of the control group. The skin status (skin texture value and skin pore value), clinical efficacy, quality of life and adverse reactions were compared between the two groups. Results The scores of quality of life in the observation group were higher than those in the control group (P