Objective To explore the application effect of comprehensive nursing intervention in patients with jaw impacted tooth extraction. Methods From May 2020 to October 2022, 80 patients with impacted tooth extraction in our hospital were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 40 cases in each group. The control group was given routine nursing intervention, and the experimental group was given comprehensive nursing intervention. The nursing satisfaction, pain degree, bad mood, compliance and quality of life were compared between the two groups. Results The total nursing satisfaction of the experimental group was 97.50%, which was higher than 80.00% of the control group (P