Objective To explore the effect of standardized nursing measures in the repair of traumatic fracture combined with soft tissue defect by continuous negative pressure drainage. Methods A total of 76 patients with traumatic fracture complicated with soft tissue defect admitted to our hospital from January 2020 to December 2022 were randomly divided into control group and observation group, with 38 cases in each group. The control group was given routine nursing, while the observation group was given standardized nursing. The clinical indexes, complications and wound aesthetics of the two groups were compared. Results The time of getting out of bed after operation in the observation group was shorter than that in the control group, the area of wound reduction was larger than that in the control group, the number of days of secondary skin grafting was less than that in the control group, and the survival rate of flap was higher than that in the control group (P