Objective To explore the effect of oral rehabilitation treatment on oral health and related quality of life in preschool children. Methods From August 2021 to September 2022, 60 children who underwent prefabricated crown or invisible denture repair in the Department of Stomatology of our hospital were selected as the research objects. Before and after treatment, Early Childhood Oral Health Impact Scale (ECOHIS) was used to evaluate children's oral health and its impact on quality of life. Results Before treatment, oral pain (75.00%) had the greatest impact on children's oral health, followed by eating difficulties (45.00%), and depression (1.67%) had the least impact. The greatest impact on their families was psychological guilt (56.67%), and the least impact was absenteeism or leave (13.33%); after treatment, the proportion of oral pain that had the greatest impact on children's oral health decreased to 8.33%, the proportion of eating difficulties decreased to 6.67%, and the proportion of psychological guilt that had the greatest impact on families decreased to 38.33%. The scores of ECOHIS scale in 60 children after treatment were lower than those before treatment, and the difference was statistically significant (P<0.05). Conclusion Oral rehabilitation treatment for preschool children is helpful to restore the corresponding function of deciduous teeth, maintain oral health, and reduce the impact on the quality of life of children and their families.