Objective To explore the application effect of small incision degreasing combined with continuous embedding double eyelid surgery in asymmetric double eyelid plastic surgery. Methods A total of 84 patients with asymmetric double eyelids admitted to our hospital from January 2022 to June were selected as the research objects and divided into observation group and control group by random number table method, with 42 cases in each group. The control group was given conventional incision double eyelid surgery, and the observation group was given small incision degreasing combined with continuous embedding double eyelid surgery. The clinical indicators, pain degree, inflammatory factor levels, aesthetics, satisfaction and complications were compared between the two groups. Results The intraoperative blood loss in the observation group was less than that in the control group, and the operation time and incision healing time were shorter than those in the control group (P<0.05). The VAS scores of the observation group at 1, 2 and 3 h after operation were lower than those of the control group (P<0.05). After operation, the levels of IL-6, CRP and TNF-α in the observation group were lower than those in the control group (P<0.05). The total aesthetic degree of the observation group was 97.62%, which was higher than 83.33% of the control group (P<0.05). The total satisfaction of the observation group was 95.24%, which was higher than 80.95% of the control group (P<0.05). The incidence of complications in the observation group was lower than that in the control group (P<0.05). Conclusion The application effect of small incision degreasing combined with continuous embedding double eyelid surgery in asymmetric double eyelid plastic surgery is definite, which can effectively reduce the pain of patients, and the postoperative recovery is fast, the inflammation is light, and the risk of complications is low. Meanwhile, it is beneficial to improve the aesthetics of the eyes, and the patient satisfaction is high, which is worthy of clinical application.