Objective To explore the therapeutic effect of Yangxue Qufeng decoction in chronic urticaria of blood deficiency and wind-heat type. Methods A total of 70 patients with chronic urticaria of blood deficiency and wind-heat type admitted to our center from January 2018 to October 2022 were selected as the research objects. According to different treatment schemes, they were divided into control group and study group, with 35 patients in each group. The control group was treated with oral olopatadine hydrochloride tablets, while the study group was treated with oral Yangxue Qufeng decoction. The clinical effect, main symptoms, urticaria activity score and immune factor level were compared between the two groups. The recurrence rate was compared between the two groups after 3 months of follow-up. Results The total effective rate of treatment in the study group was 94.29%, which was higher than 77.14% in the control group, and the difference was statistically significant (P<0.05). After treatment, the number of wheals, itching degree, edema degree and skin scratch score of the two groups were lower than those of the treatment, and those in the study group was lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, the UAS score of the two groups was lower than that before treatment, and that in the study group was lower than that in the control group, the difference was statistically significant (P<0.05). After treatment, the levels of IL-4, LT and IgE in the two groups were lower than those before treatment, the level of IFN-γ was higher than that before treatment, and the levels of immune factors in thestudy group were better than those in the control group, the differences were statistically significant (P<0.05). After 3 months of follow-up, the recurrence rate of the study group was 5.71%, which was lower than 22.86% of the control group, the difference was statistically significant (P<0.05). Conclusion Yangxue Qufeng decoction can effectively relieve clinical symptoms and regulate the levels of immune factors. Meanwhile, the curative effect is definite and the recurrence rate is low. It has positive significance for promoting the rehabilitation of patients with chronic urticaria of blood deficiency and wind-heat type.