Objective To explore the efficacy and safety of different band filters in the treatment of facial acne vulgaris under the treatment mode of advanced optimal pulse technology (AOPT). Methods A total of 112 patients with acne admitted to our hospital from January 2019 to August 2022 were selected as the research objects. According to the random number table method, they were divided into control group（n=45）and observation group（n=65）. The control group was treated with 590 nm filter, and the observation group was treated with ultra dual-band filters. The clinical efficacy, skin physiological indexes and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 94.03%, which was higher than 82.22% of the control group (P<0.05). After treatment, the transepidermal water loss rate and erythema index of the two groups were lower than those before treatment, and the observation group was lower than the control group (P<0.05). The water content of stratum corneum and elasticity index were higher in the two groups after treatment was higher than that before treatment, and that of the observation group was higher than that of the control group (P<0.05). The incidence of skin dryness, skin itching and skin flushing in the observation group were lower than those in the control group (P<0.05). Conclusion There are some differences in the effectiveness of different band filters of advanced optimal pulse technology in the treatment of facial acne vulgaris. The curative effect of Ultra dual-band filters is better than that of 590 nm filter, which can effectively improve the skin state of patients and reduce the incidence of adverse reactions.