Chronic wounds are a type of incurable trauma that often requires long-term treatment and care. Negative pressure drainage is a commonly used method for the treatment of chronic wounds, which can promotes wound healing and rehabilitation by applying negative pressure on the wound. As a traditional drug treatment method, traditional Chinese medicine preparations have also been widely used in the treatment of chronic wounds in recent years. This article introduces the application of negative pressure drainage combined with traditional Chinese medicine preparations in the treatment of chronic wounds, and puts forward reasonable application measures in combination with the actual situation, in order to provide some reference and guidance for the study of chronic wound treatment.