Objective To explore the monitoring of coronary heart disease (CHD) through femoral artery puncture site and the management and teaching method of epidermal incision scar. Methods From June to July 2022, 8 clinicians in the Department of Cardiac Surgery of our hospital were selected as training objects to train the monitoring of coronary heart disease transfemoral artery puncture site and the management of epidermal incision scar. Totally 23 patients with coronary heart disease who underwent transfemoral artery puncture during the same period were selected as the observation group, 23 patients with coronary heart disease who underwent transfemoral artery puncture from April to May 2022 were selected as the control group. The incidence of puncture point bleeding, the incidence of epidermal incision complications, the formation of epidermal incision scar the degree of epidermal skin injury and satisfaction were compared between the two groups. Results The incidence of puncture point bleeding in the observation group was 4.35%, which was lower than 17.39% in the control group (P<0.05). The incidence of epidermal incision complications in the observation group was 8.70%, which was lower than 21.74% in the control group (P<0.05). The thickness, length and width of epidermal incision scar in the observation group were less than those in the control group (P<0.05). The proportion of normal epidermal skin and Ⅰ degree injury in the observation group were higher than those in the control group, and the proportion of Ⅱ degree injury was lower than that in the control group (P<0.05). The satisfaction in the observation group was 95.65%, which was higher than 82.61% in the control group (P<0.05). Conclusion The monitoring of coronary heart disease through femoral artery puncture site and management and teaching methods of epidermal incision scar have good results, which can reduce the bleeding rate of puncture point and the incidence of epidermal incision complications, reduce the damage to epidermal skin, improve the thickness, length and width of epidermal incision scar, and improve patient satisfaction.