China has a vast territory, and the climate differences between different places are very obvious. Among them, the climate characteristics of northern China are hot summer and cold winter. When exposed to moderate cold, normal people can cause skin vasoconstriction, followed by vasodilation to maintain blood perfusion. Mild cold injury can cause frostbite. Patients with frostbite will have persistent spasm and contraction of thicker skin arterioles, persistent expansion of thinner superficial blood vessels, blood stasis and local tissue hypoxia, resulting in tissue damage. If the duration is long, the internal and external environment of the cell changes, which evolves into severe frostbite, vascular paralytic expansion, venous congestion, increased permeability, and plasma infiltration into the tissue gap, causing edema, which can cause permanent dysfunction and seriously endanger human health. Therefore, it is of great significance to carry out scientific and effective treatment in time for frostbite. This article reviews the research progress of frostbite treatment drugs, in order to provide some reference for clinical selection of related frostbite drugs.