Objective To investigate the clinical effect of maxillary sinus elevation combined with guided bone regeneration technique for maxillary posterior tooth implant restoration. Methods Sixty patients with missing teeth in the maxillary posterior region admitted to Liaocheng Veterans Hospital from July 2021 to September 2022 were selected as study subjects and divided into control group and experimental group according to the random number table method, with 30 patients in each group. The control group was restored by CBCT-guided external maxillary sinus elevation alone, and the experimental group was restored by CBCTguided external maxillary sinus elevation combined with guided bone regeneration technique. The success rate of implantation, bone thickness, bone density and chewing after repair were compared between the two groups. Results The success rate of implantation, bone mineral density, bone thickness and masticatory efficiency in the experimental group were higher than those in the control group (P<0.05). Conclusion The maxillary posterior dental implant restoration treated with maxillary sinus elevation combined with guided bone regeneration technique is more effective, which can improve the success rate of implant treatment and the bone density and bone thickness of implant placement area, and improve the masticatory efficiency of patients, and is worthy of clinical application.