Objective To explore the preventive effect of early nursing intervention on nasal and facial bedsore in patients with chronic obstructive pulmonary disease undergoing non-invasive positive pressure ventilation. Methods A total of 56 patients with chronic obstructive pulmonary disease who received non-invasive positive pressure ventilation in our hospital from June 2021 to December 2022 were selected as the research objects. They were randomly divided into conventional group and study group, with 28 patients in each group. The conventional group received basic nursing, and the control group received early nursing intervention. The pulmonary function indexes, incidence of adverse reactions, incidence of nasal and facial bedsores were compared between the two groups. Results The FEV1, FVC and FEV1/FVC indexes of the two groups after nursing were better than those before nursing, and the study group was better than that of the conventional group (P<0.05). The incidence of adverse reactions in the study group was 3.57%, which was lower than 17.85% in the conventional group (P<0.05). The incidence of nasal and facial bedsore in the study group was 3.57%, which was lower than 14.28% in the conventional group (P<0.05). Conclusion Early nursing intervention has a more accurate preventive effect on nasal and facial pressure ulcers in patients with chronic obstructive pulmonary disease undergoing non-invasive positive pressure ventilation, and can reduce the incidence of adverse reactions, with higher application value.