Supramolecular salicylic acid, as a controlled and sustained-release formulation of salicylic acid, has antiinflammatory, antibacterial, and bidirectional cutin regulation effects on the skin, so it has been widely used in the clinical treatment of skin diseases in recent years. This paper introduces the mechanism of supramolecular salicylic acid in detail, and reviews the application of supramolecular salicylic acid in dermatology, including acne, acne rosacea, chloasma, postinflammatory melanosis and other skin diseases, so as to provide reference for the clinical application of supramolecular salicylic acid.