健脾解毒汤联合阿维A 治疗红皮病型银屑病的临床效果
作者:
作者简介:

许明明(1983.11-),女,新疆昌吉人,硕士,主治医师,主要从事皮肤病临床诊治工作

中图分类号:

R758.63


Clinical Effect of Jianpi Jiedu Decoction Combined with Acitretin in the Treatment of Erythrodermic Psoriasis
Author:
  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献 [14]
  • |
  • 相似文献 [20]
  • | | |
  • 文章评论
    摘要:

    目的 探究健脾解毒汤联合阿维A治疗红皮病型银屑病的临床效果。方法 选取2018年7月-2022年7月 于新疆医科大学第一附属医院昌吉分院就诊的红皮病型银屑病患者56例,按照随机数字表法分为观察组和 对照组,每组28例。对照组采用阿维A进行治疗,观察组在对照组基础上采用健脾解毒汤进行治疗,比较两 组临床疗效、促炎细胞因子[肿瘤坏死因子(TNF-ɑ)、白细胞介素6(IL-6)、白细胞介素8(IL-8)]水 平、银屑病皮损面积严重程度(PASI评分)、皮肤病生活质量指数(DLQI)评分、中医证候积分及 不良反应发生情况。结果 观察组治疗总有效率为96.42%,高于对照组的82.14%(P <0.05);观察组 治疗后TNF-ɑ、IL-6、IL-8水平低于对照组(P <0.05);观察组治疗后PASI及DLQI评分低于对照 组(P <0.05);观察组治疗后中医证候积分低于对照组(P <0.05);两组不良反应发生率比较,比较差 异无统计学意义(P >0.05)。结论 健脾解毒汤联合阿维A治疗红皮病型银屑病具有较好的效果,能降低 促炎性细胞因子水平,改善患者临床症状,具有一定的安全性。

    Abstract:

    Objective To explore the clinical efficacy of Jianpi Jiedu decoction combined with acitretin in the treatment of erythrodermic psoriasis. Methods A total of 56 patients with erythrodermic psoriasis who were treated in Changji Branch of the First Affiliated Hospital of Xinjiang Medical University from July 2018 to July 2022 were selected and divided into observation group and control group according to the random number table method, with 28 patients in each group. The control group was treated with acitretin, and the observation group was treated with Jianpi Jiedu Decoction on the basis of the control group. The clinical efficacy, proinflammatory cytokines [tumor necrosis factor (TNF-ɑ), interleukin 6 (IL-6), interleukin 8 (IL-8)] levels, psoriasis area severity (PASI score), skin disease quality of life index (DLQI) score, TCM syndrome score and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 96.42%, which was higher than 82.14% of the control group (P <0.05). The levels of TNF-ɑ, IL-6 and IL-8 in the observation group were lower than those in the control group (P <0.05). After treatment, the PASI and DLQI scores of the observation group were lower than those of the control group (P <0.05). After treatment, the scores of TCM syndromes in the observation group were lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P >0.05). Conclusion Jianpi Jiedu decoction combined with acitretin in the treatment of erythrodermic psoriasis has a good curative effect, which can reduce the level of pro-inflammatory cytokines, improve the clinical symptoms of patients, and has certain safety.

    参考文献
    [1] Jin X,Xu H,Huang C,et al.A Traditional Chinese Medicine Formula Danshen Baibixiao Ameliorates Imiquimod- Induced Psoriasis-Like Inflammation in Mice[J].Front Pharmacol,2021,12:749626.
    [2] Sch?bitz A,Eyerich K,Garzorz-Stark N.So close,and yet so far away:The dichotomy of the specific immune response and inflammation in psoriasis and atopic dermatitis[J].J Intern Med,2021,290(1):27-39.
    [3] 杨道秋,姜岩峰.观察复方甘草酸苷导入联合小剂量 阿维A治疗红皮病型银屑病的效果[ J ] .世界复合医 学,2022,8(8):174-177.
    [4] 王玥,严煜林.寻常型银屑病患者171例阿维A治疗相关不良 反应及停药原因分析[J].中华皮肤科杂志,2022,55(3):242- 245.
    [5] 蒋晓妍,刘克帅,张晓艳.阿维A胶囊联合复方甘草酸苷治 疗红皮病型银屑病的疗效及安全性Meta分析[J].中国中 西医结合杂志,2022,42(5):568-574.
    [6] 杨广义.小柴胡汤合麻杏石甘汤治疗红皮病型银屑病的 疗效及对预防患者高热的价值分析[J].中外女性健康研 究,2021(12):55-56,94.
    [7] 张步鑫,王丽,王庆兴,等.薏苡败酱汤加减治疗寻常 型银屑病湿热蕴结证的临床研究[ J ] . 中国中药杂 志,2022,47(11):3105-3110.
    [8] 宫克,郭建辉,郭雯,等.凉血退疕汤治疗血热证寻常性银 屑病患者的临床效果[J].中国医药导报,2022,19(16):127- 130,146.
    [9] Wang Q,Zhang H,Dai SM.Differentiating psoriatic arthritis sine psoriasis from seronegative rheumatoid arthritis-Experiences from five patients[J].Int J Rheum Dis,2022,25(9):1088-1092.
    [10] 陈芳,郭顺,施建新.白庀合剂联合西药治疗血热风燥型银屑 病的疗效观察[J].世界中西医结合杂志,2021,16(11):2051- 2055,2060.
    [11] 彭文文,杨志波.中西医结合治疗泛发性脓疱型银屑病 合并红皮病型银屑病伴发多重耐药表皮葡萄球菌血流 感染1例[J].中医药导报,2021,27(4):204-206.
    [12] 李鹏英,丰靓,刘红霞.中药2号方联合健脾解毒汤治疗 寻常型银屑病脾虚湿盛证的疗效观察及对外周血T淋巴 细胞的表达影响[J].中华中医药学刊,2019,37(11):2609- 2613.
    [13] 沈萍,丁黎薇,张春娟.消疕通络汤治疗银屑病关节炎湿 热痹阻证的效果及对血清IL-6、TNF-α水平的影响[J].中 国医学创新,2022,19(8):92-95.
    [14] 刘朝霞,郭菲,李斌,等.健脾解毒汤对脾虚湿盛型寻常型 银屑病小鼠白细胞介素-17及其相关炎症因子的影响[J]. 中华中医药杂志,2022,37(8):4680-4683.
    引证文献
    网友评论
    网友评论
    分享到微博
    发 布
引用本文

许明明.健脾解毒汤联合阿维A 治疗红皮病型银屑病的临床效果[J].医学美学美容,2023,32(9):44-47.

复制
分享
文章指标
  • 点击次数:81
  • 下载次数: 0
  • HTML阅读次数: 0
  • 引用次数: 0
历史
  • 在线发布日期: 2023-07-29