Objective To observe the clinical efficacy of eyelid suture embedding and orbicularis oculi muscle muscle resection in the treatment of senile entropion. Methods A total of 40 patients (62 eyes) with senile entropion undergoing elective surgery admitted to Nanjing Lishui People's Hospital from January 2019 to June 2022 were selected as the research objects. They were divided into control group and observation group by random number table method, with 20 patients in each group. The control group was treated with orbicularis oculi muscle resection, and the observation group was treated with eyelid suture embedding method. The tear film rupture time (BUT), tear secretion test (SIt), corneal fluorescence staining (CFS), recurrence and complications were compared between the two groups. Results At 1 and 3 months after operation, BUT and SIt in the two groups were higher than those before operation, and CFS was lower than that before operation (P <0.05). There was no significant difference in BUT, SIt and CFS between the two groups (P >0.05). There was no significant difference in the recurrence rate between the two groups (P >0.05). There were no serious complications such as eyelid infection, lower eyelid separation, lower eyelid deficiency or excess in both groups. Conclusion For patients with senile entropion, both eyelid suture embedding and orbicularis oculi muscle muscle resection can improve their ocular surface status and improve the stability of tear film on the ocular surface. However, eyelid catgut embedding is simpler to operate and does not require stitches, and patients have higher comfort