Objective To observe the effect of dental implant repair on implant survival rate and inflammatory factors in gingival crevicular fluid in patients with chronic periodontitis and dentition defect. Methods From July 2020 to March 2022, 100 patients with dentition defect who received dental implant repair in the Affiliated Stomatological Hospital of Guilin Medical College were selected as the research objects. According to whether they were accompanied by chronic periodontitis, they were divided into control group (periodontal health) and observation group (with chronic periodontitis), with 50 patients in each group. The control group was treated with conventional dental implant repair, and the observation group was treated with dental implant repair after systemic periodontitis treatment. The implant survival rate, gingival crevicular fluid inflammatory factor level and periodontal index were compared between the two groups. Results The implant survival rate of the observation group was 100.00%, which was higher than 96.00% of the control group, but the difference was not statistically significant (P>0.05). The levels of TNF-α, hs-CRP, IL-2 and IL-8 in the observation group were higher than those in the control group before and after oral repair (P<0.05). The CAL, PLI and PD in the observation group were higher than those in the control group before oral repair (P<0.05). There was no significant difference in CAL, PLI and PD between the two groups after oral repair (P>0.05). Conclusion The effect of dental implant repair in patients with chronic periodontitis is definite. Compared with periodontal healthy patients,there is no significant difference in the curative effect, and it will not increase the inflammatory reaction of gingival crevicular fluid, and can effectively improve the periodontal index of patients.