Objective To explore the clinical effect of zirconia all-ceramic crown in upper and lower anterior teeth restoration. Methods From January 2021 to January 2023, 50 patients with upper and lower anterior teeth restoration admitted to the Department of Stomatology of our hospital were selected as the research objects. They were divided into control group and observation group by random number table method, with 25 patients in each group. The control group was treated with conventional nickel-chromium alloy restoration, and the observation group was treated with zirconia all-ceramic crown restoration. The repair effect, complications, bite force, periodontal condition and inflammatory factor level were compared between the two groups. Results The total effective rate of repair in the observation group was 100.00%, which was higher than 76.00% in the control group (P<0.05). The incidence of complications in the observation group was 4.00%, which was lower than 20.00% in the control group (P<0.05). The bite force of the observation group was higher than that of the control group (P<0.05). The gingival index and plaque index of the observation group were lower than those of the control group, and the periodontal probing depth was higher than that of the control group (P<0.05). The levels of IL-6 and IL-8 in the observation group were lower than those in the control group (P<0.05). Conclusion The application of zirconia all-ceramic crown in upper and lower anterior teeth restoration is effective, which can improve the repair effect, improve the periodontal index, control the inflammatory reaction, and improve the aesthetics of teeth. Meanwhile, the incidence of complications after repair is small, and the safety is high.