Objective To explore the application effect of comprehensive nursing intervention in patients undergoing breast augmentation with prosthesis implantation. Methods From January 2022 to February 2023, 80 patients who underwent breast augmentation with prosthesis implantation in our hospital were selected as the research objects. According to the different admission time, they were divided into control group and observation group, with 40 patients in each group. The control group was given routine nursing intervention, and the observation group was given comprehensive nursing intervention. The nursing effect, bad mood, complications and nursing satisfaction of the two groups were compared. Results The total effective rate of nursing in the observation group was 95.00%, which was higher than 77.50% in the control group (P<0.05). The complication rate of the observation group was 10.00%, which was lower than 30.00% of the control group (P<0.05). After intervention, the SAS score and SDS score of the observation group were lower than those of the control group (P<0.05). The satisfaction scores of nursing effectiveness, immediacy, nursing attitude and health education in the observation group were higher than those in the control group (P<0.05). Conclusion The application of comprehensive nursing intervention in patients undergoing breast augmentation with prosthesis implantation is effective, which can eliminate the patient's bad mood in time, reduce complications, and effectively improve the nursing effect. Meanwhile, the patient's satisfaction with the nursing service is high, which is worthy of clinical application.