Objective To explore the therapeutic effect of facial liposuction combined with autologous fat filling surgery on facial contour remodeling. Methods A total of 200 patients who underwent facial contour remodeling in our hospital from January 2021 to January 2022 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 100 patients in each group. The control group was treated with facial liposuction combined with sodium hyaluronate filling, and the observation group was treated with facial liposuction combined with autologous fat filling. The effective rate, treatment satisfaction and complication rate were compared between the two groups. Results The total effective rate of treatment in the observation group was 95.00%, which was higher than 78.00% in the control group, and the difference was statistically significant (P