Objective To explore the effect of comprehensive therapy in patients with chest and back keloids. Methods A total of 85 patients with chest and back keloids admitted to our hospital from April 2020 to April 2022 were selected as the research objects and randomly divided into control group (n=43) and observation group (n=42). The control group was treated with conventional therapy, and the observation group was treated with comprehensive therapy. The clinical efficacy, recurrence rate and patient satisfaction were compared between the two groups. Results The total effective rate of treatment in the observation group was 95.24%, which was higher than 79.07% in the control group, and the difference was statistically significant (P