Objective To explore the application effect of comprehensive nursing intervention in children with urticaria. Methods A total of 34 children with urticaria admitted to our hospital from March 2021 to March 2023 were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 17 children in each group. The control group was given routine nursing, and the observation group was given comprehensive nursing intervention on the basis of the control group. The nursing effect, time index and nursing satisfaction of the two groups were compared. Results The total effective rate of nursing in the observation group was 100.00%, which was higher than 76.47% in the control group, and the difference was statistically significant (P