Objective To explore the nursing effect of psychological nursing on patients undergoing replantation of amputated finger. Methods A total of 70 patients with replantation of amputated finger admitted to our hospital from January 2021 to February 2022 were randomly divided into routine group and study group, with 35 patients in each group. The routine group was given routine nursing, and the study group was given psychological nursing. The quality of life, nursing satisfaction, comfort, anxiety and depression were compared between the two groups. Results The nursing satisfaction of the study group was higher than that of the routine group, and the difference was statistically significant (P