Objective To study the application effect of continuous nursing intervention in patients with oral rehabilitation. Methods A total of 50 patients who underwent oral rehabilitation in our hospital from April 2020 to July 2022 were selected and divided into routine group (n=25) and observation group (n=25) according to different nursing measures. The routine group was given routine nursing, and the observation group was given continuous nursing. The nursing effect, treatment compliance and quality of life were compared between the two groups. Results The total effective rate of treatment in the observation group was 100.00%, which was higher than 80.00% in the conventional group, and the difference was statistically significant (P<0.05). The degree of compliance in the observation group was 100.00%, which was higher than 76.00% in the conventional group, the difference was statistically significant (P<0.05). The scores of physiological function, emotional function, physical pain, activity, social function, mental health and overall health in the observation group were higher than those in the conventional group, and the differences were statistically significant (P<0.05). Conclusion The clinical efficacy of continuous nursing for patients with oral rehabilitation is definite, which can improve the treatment compliance and quality of life of patients