Objective To explore the application effect of whole-course psychological nursing intervention in outpatients with double eyelid surgery. Methods 60 outpatients with double eyelid surgery admitted to Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University from February 2022 to February 2023 were selected as the research objects. They were randomly divided into control group (30 cases, routine nursing intervention) and observation group (30 cases, whole course psychological nursing intervention). The nursing satisfaction, compliance behavior, negative emotion score, pain score and complications were compared between the two groups. Results The nursing satisfaction of the observation group was 96.67%, which was higher than 76.67% of the control group (P<0.05). The scores of diet and rest compliance behavior in the observation group were higher than those in the control group (P<0.05). The negative emotion score and VAS score of the observation group after nursing were lower than those of the control group (P<0.05). The incidence of complications in the observation group was 3.33%, which was lower than 20.00% in the control group (P<0.05). Conclusion The whole-course psychological nursing has a high application value in the clinical nursing work of outpatients with double eyelid surgery. It not only helps to improve the negative emotions of patients, but also strengthens the compliance behavior of patients, reduces the incidence of complications, and contributes to the continuous improvement of nursing quality