In order to explore the cosmetic effect of type A botulinum toxin in the treatment of facial wrinkles, this study selected 50 patients who underwent facial wrinkle repair in our hospital from January 2021 to January 2023 as the research object. All patients were treated with type A botulinum toxin, and the clinical treatment effect and adverse reactions were observed. The results showed that the total effective rate of treatment was as high as 98.00%, and the incidence of adverse reactions was low, only 4.00%. It can be seen that type A botulinum toxin is effective in the treatment of facial wrinkles, the treatment process is safe, which is worthy of clinical application