Objective To analyze the effect of emedastine difumarate sustained-release capsules combined with collagen dressing in the treatment of facial glucocorticoid-dependent dermatitis. Methods A total of 120 patients with facial glucocorticoid-dependent dermatitis admitted to Taizhou Center for Disease Control and Prevention from March 2020 to December 2021 were randomly divided into reference group and study group, with 60 patients in each group. The reference group was treated with emedastine difumarate sustained-release capsules. The study group was treated with collagen dressing on the basis of the reference group. The symptom scores, facial skin function, inflammatory indexes and incidence of adverse reactions were compared between the two groups. Results After treatment, the scores of skin pain, skin itching and skin burning in the two groups were lower than those before treatment, and those in the study group were lower than those in the reference group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion In the treatment of facial glucocorticoid-dependent dermatitis, the treatment of emedastine difumarate sustained-release capsules combined with collagen dressing can better alleviate facial symptoms, improve facial skin function, and control inflammatory response. Meanwhile, the combined use of drugs does not increase the incidence of adverse reactions, which is worthy of clinical application.