富马酸依美斯汀缓释胶囊联合胶原贴敷料治疗面部糖皮质激素依赖性皮炎的效果
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盛宏(1978.10-),男,江苏泰州人,本科,副主任医师,主要从事皮肤过敏性疾病以及损容性皮肤疾病的诊断与治疗 相关研究

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R751

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Effect of Emedastine Difumarate Sustained-release Capsules Combined with Collagen Dressing in the Treatment of Facial Glucocorticoid-dependent Dermatitis
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    摘要:

    目的 探究富马酸依美斯汀缓释胶囊联合胶原贴敷料治疗面部糖皮质激素依赖性皮炎的效果。 方法 选取2020年3月-2021年12月泰州市疾病预防控制中心收治的120例面部糖皮质激素依赖性皮炎患者 作为研究对象,随机分为参照组和研究组,各60例。参照组予以富马酸依美斯汀缓释胶囊治疗,研究 组在参照组基础上加入胶原贴敷料治疗,比较两组症状积分、面部皮肤功能、炎性指标以及不良反应 发生率。结果 两组治疗后皮肤疼痛、皮肤瘙痒以及皮肤灼热评分均低于治疗前,且研究组低于参照组 (P<0.05);两组治疗后面部表皮油脂高于治疗前,且研究组高于参照组(P<0.05);两组治疗后经皮 水分丢失量、皮肤红斑量低于治疗前,且研究组低于参照组(P<0.05);两组治疗后IL-2低于治疗前,且 研究组低于参照组,两组IFN-γ高于治疗前,且参照组低于研究组(P<0.05);两组不良反应发生率比 较,差异无统计学意义(P>0.05)。结论 面部糖皮质激素依赖性皮炎在治疗的过程中给予富马酸依美斯 汀缓释胶囊联合胶原贴敷料治疗可更好的缓解面部症状,改善面部皮肤功能,控制炎症反应,药物联合使 用未增加不良反应发生率,值得临床应用。

    Abstract:

    Objective To analyze the effect of emedastine difumarate sustained-release capsules combined with collagen dressing in the treatment of facial glucocorticoid-dependent dermatitis. Methods A total of 120 patients with facial glucocorticoid-dependent dermatitis admitted to Taizhou Center for Disease Control and Prevention from March 2020 to December 2021 were randomly divided into reference group and study group, with 60 patients in each group. The reference group was treated with emedastine difumarate sustained-release capsules. The study group was treated with collagen dressing on the basis of the reference group. The symptom scores, facial skin function, inflammatory indexes and incidence of adverse reactions were compared between the two groups. Results After treatment, the scores of skin pain, skin itching and skin burning in the two groups were lower than those before treatment, and those in the study group were lower than those in the reference group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion In the treatment of facial glucocorticoid-dependent dermatitis, the treatment of emedastine difumarate sustained-release capsules combined with collagen dressing can better alleviate facial symptoms, improve facial skin function, and control inflammatory response. Meanwhile, the combined use of drugs does not increase the incidence of adverse reactions, which is worthy of clinical application.

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盛 宏,潘 龙.富马酸依美斯汀缓释胶囊联合胶原贴敷料治疗面部糖皮质激素依赖性皮炎的效果[J].医学美学美容,2023,32(13):64-67.

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  • 在线发布日期: 2023-09-26
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