Objective To investigate the clinical effect of Quxuan Zhiyang lotion combined with miconazole nitrate cream in the treatment of keratotic tinea pedis. Methods A total of 80 patients with keratotic tinea pedis admitted to Xiaojihan Town Health Center in Yuyang District from January 2020 to January 2023 were selected as the research objects. They were divided into experimental group and control group by random number table method, with 40 patients in each group. The control group was treated with miconazole nitrate cream, and the experimental group was treated with Quxuan Zhiyang lotion combined with miconazole nitrate cream. The clinical efficacy, symptom and sign scores and fungal clearance rate were compared between the two groups. Results The total effective rate of treatment in the experimental group was 95.00%, which was higher than 72.50% in the control group (P