Objective To explore the effect of yeast recombinant collagen repair dressing on allergic dermatitis. Methods A total of 80 patients with allergic dermatitis treated in our hospital from April 2022 to April 2023 were randomly divided into control group and experimental group, with 40 patients in each group. The control group received routine drug treatment, and the experimental group was treated with yeast recombinant collagen repair dressing on the basis of routine treatment. The clinical efficacy, symptom scores, skin barrier function indexes, incidence of adverse reactions and recurrence rate were compared between the two groups. Results The total effective rate of treatment in the experimental group was higher than that in the control group, and the difference was statistically significant (P