Objective To explore the application effect of comprehensive nursing in patients with nasal comprehensive plastic surgery during perioperative period. Methods A total of 53 patients who underwent comprehensive rhinoplasty in our hospital from June 2020 to June 2022 were selected as the research objects. According to the random number table method, they were divided into the traditional group (n=27) and the exploration group (n=26). The traditional group was treated with routine nursing, and the exploration group was treated with comprehensive nursing. The nursing satisfaction and complications of the two groups were compared. Results The scores of each dimension of nursing satisfaction in the exploration group were higher than those in the control group (P